GENETICS

GENETICS FACTORS TO AGING

While it has long been recognized that environmental and lifestyle factors play a key role in skin aging, the advance of more reliable DNA research have shown that as much as 60% of aging is dependent on genetic factors.

WHAT IS DNA?

The DNA (DeoxyriboNucleic Acid) carries all the genetic coding for living organisms with the instructions needed for growth, development and functions.

The famous double-spiral (X) is made up of nucleotides, consisting of polymers of sugar linked to phosphate, with one each of four different nitrogen bases (G, T, A and C) attached to the nucleotides.

The sequence of the different nucleotides is highly identical within a species, but thousands of variations at specific points of the genome occur. These are called Single Nucleotide Polymorphism, or more commonly known as a SNP.

The SNP’s are variations that can explain differences in your appearance, aging and fitness.

DIFFERENT TYPES OF AGING 

There are 5 different types of aging that are affected both by genetical factors as well as environmental and lifestyle factors.

Intrinsic-Aging – Your Skin’s Structure

Collagen and elastin fibers form a structure that maintains the skins firmness and elasticity. One factor that disrupts collagen formation is MMP (Matrix MetalloProteinase), causing the skin to lose its natural plumpness and volume and creating fine lines, sagging and deeper wrinkle formation.

We call this category the ALLÉL® X-Series

Glyc-Aging – Your Skin’s Energy

Glycation is the process that occurs when sugars (glucose molecules) bind on to collagen and elastin, degrading these vital skin fibers. As a result, a substance called A.G.E is formed – Advanced Glycation End-products. A.G.E leads to an internal aging process with a loss of skin elasticity, reduced ability to regenerate and deep skin wrinkling.

We call this category the ALLÉL® G-Series

Photo-Aging – Your Skin’s Pigmentation

Sun exposure plays a significant factor in aging of the skin. When the skin is exposed to the sun, damage can occur at a molecular level, causing a breakdown in the DNA. This then leads to skin aging signs such as dryness, loss of elasticity, wrinkles and an uneven skin tone known as pigmentation.

We call this category the ALLÉL® T-Series

Oxid-Aging – Your Skin’s Defense

Free radicals are reactive molecules that harm important cellular structures of our skin. These molecules may accumulate as a result of exposure to pollution, stress and smoking. If the body’s own anti-oxidative capacity is overwhelmed, oxidative stress may occur in the skin. This is considered a leading cause of premature wrinkling, aging and dull skin.

We call this category the ALLÉL® A-Series

Inflamm-Aging – Your Skin’s Sensitivity

The skin’s epidermal layer is a protective barrier that is designed to keep out harmful substances whilst locking in moisture to maintain a healthy skin barrier. Various agents can cause skin irritation including perfume, chemicals and pollution. Although inflammation is the natural response to external stimuli it may, over time, cause a weakening in the skin.

We call this category the ALLÉL® C-Series

ALLÉL® Power of Prediction

With the help of advanced DNA technology we have defined 16 SNP’s that has all been verified in two independent peer-reviewed publications. Our DNA test has also been validated in over 800 samples at an external laboratory using PCR and Sanger sequencing which gave a 100% agreement in test results.

The 16 SNP’s will measure the key drivers behind your aging and they are following the 5 different types of aging

Category X – Matrix

3 SNP’s, located on genes MMP1 and GPX1, which affect the skin’s degradation and protection of collagen.

Category G – Glycation

1 SNP, located on gene TCF7L2, which affects the level of glucose which in turn affects glycation.

Category T – Tone

5 SNP’s, located on genes ASIP, MC1R, XRCC1 and ERCC1, affecting the skin cell’s melanin production and defense of UV damage.

Category A – Antioxidant

3 SNP’s, located on genes SOD2, GPX1 and NQO1, that protects the skin against oxidative stress and pollution.

Category C – Calming

5 SNP’s, located on genes TNF, GSTP1, RTEL1 and EPHX1, which affect the skin’s protection against inflammation.